Hemoglobin Electrophoresis Interpretation Guidelines

Normal Hemoglobin Patterns

• The normal adult hemoglobin pattern is characterized by Hgb A levels between 96-98%, as stated by the American College of Medical Genetics, with the given result showing Hgb A at 97.8% 1

Clinical Significance and Recommendations

• The British Society of Gastroenterology guidelines recommend investigating alternative causes of microcytosis, such as anemia of chronic disease, when microcytosis occurs with normal iron studies and normal hemoglobin electrophoresis, emphasizing the importance of considering other causes when hemoglobin electrophoresis results are normal 2, 3
• The presence of a normal Hgb A2 level, specifically 2.2% in this case, excludes beta-thalassemia trait, which would typically show elevated Hgb A2 levels above 3.3%, according to the British Society of Gastroenterology guidelines 2, 3