Guideline Recommendations for Initial Lisinopril Dosing in Hypertension

Initial Combination Therapy Emphasis

• The 2025 American Heart Association/American College of Cardiology (AHA/ACC) guidelines and the 2024 European Society of Cardiology (ESC) guidelines recommend initiating combination therapy for most patients with confirmed hypertension (blood pressure ≥ 140/90 mmHg); when lisinopril is used as monotherapy, a starting dose of 10 mg once daily is considered appropriate. 1, 2

Stepped‑Care Approach for Select Populations

• Both guidelines indicate that a stepped‑care strategy—beginning treatment with a single antihypertensive agent—is reasonable for patients with stage 1 hypertension, older adults, and individuals with a prior history of hypotension or drug‑related side effects. 1