Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/13/2025

Management of Viral Conjunctivitis

Clinical Presentation and Diagnosis

  • The American Academy of Ophthalmology guidelines state that viral conjunctivitis presents with watery discharge, photosensitivity, and pain, which are distinguishing features from bacterial conjunctivitis 1, 2
  • The triad of watery discharge, photosensitivity, and pain strongly suggests viral conjunctivitis rather than bacterial or other etiologies 1, 2
  • Photosensitivity (photophobia) indicates corneal involvement, commonly seen with adenoviral keratoconjunctivitis or herpes simplex virus 1, 2, 4
  • Pain (rather than just irritation) suggests more significant inflammation, typical of viral causes 1, 5

Treatment and Management

  • The American Academy of Ophthalmology recommends supportive care as the initial management for viral conjunctivitis, as it is self-limited and does not benefit from antibiotics or antiviral therapy in most cases 1, 2, 3
  • Topical antibiotics are not indicated for viral conjunctivitis, as they only shorten the duration of bacterial conjunctivitis by approximately 1 day and promote resistance 1, 4
  • Topical antivirals are not routinely indicated for viral conjunctivitis, except for herpes simplex virus (HSV) conjunctivitis with distinctive signs 1, 2
  • The 2024 guidelines support the use of artificial tears for symptomatic relief, cold compresses to reduce inflammation and discomfort, and strict hand hygiene to prevent transmission to others and the contralateral eye 4

Referral and Transmission Prevention

  • The American Academy of Ophthalmology emphasizes that certain features, such as decreased vision, severe pain, corneal involvement, recent ocular surgery, and vesicular rash on eyelids or nose, mandate urgent ophthalmology referral 1, 2, 4
  • Viral conjunctivitis is highly contagious, and patients should avoid touching their eyes, practice frequent handwashing, and avoid sharing towels, pillowcases, or eye cosmetics 4