Antibiotic Treatment for Vibrio Vulnificus Infections

First-Line Treatment Options

• The recommended first-line treatment for Vibrio vulnificus infections is doxycycline plus a third-generation cephalosporin, such as ceftriaxone or cefotaxime, as suggested by the Infectious Diseases Society of America 1, 2
• Combination therapy with doxycycline 100 mg IV every 12 hours plus ceftriaxone 1-2 g IV every 24 hours is a recommended treatment option 2
• Alternatively, doxycycline 100 mg IV every 12 hours plus cefotaxime 1-2 g IV every 8 hours is also a recommended combination therapy 1, 2

Clinical Presentations and Treatment Considerations

Necrotizing Skin and Soft Tissue Infections

• Aggressive wound care and fasciotomy may be necessary for necrotizing infections, in addition to antibiotic therapy, as recommended by the Infectious Diseases Society of America 2