Safe Oxycodone Prescription Guidelines

Introduction to Oxycodone Prescription

• The Centers for Disease Control and Prevention, as reported by MMWR Recommendations and Reports, suggests that limiting the daily intake of oxycodone to 6 tablets per day is appropriate to avoid overdose 1

Dosage and Equivalence Considerations

• The morphine equivalence of oxycodone is 1.5 times that of morphine, and the proposed maximum dose (6 tablets of 5 mg = 30 mg/day) corresponds to 45 mg of morphine equivalent per day, which remains below the increased vigilance threshold of 50 MME/day 1
• The dose of oxycodone should be carefully controlled to minimize the risks of adverse effects and dependence, as recommended by MMWR Recommendations and Reports 1

Ongoing Monitoring and Dose Adjustment

• The dose of oxycodone must be reevaluated regularly based on analgesic efficacy and adverse effects, according to MMWR Recommendations and Reports 1