Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/31/2025

Naproxen for Carpal Tunnel Syndrome: Alternative Therapies

Introduction to Alternative Therapies

  • The American College of Cardiology recommends naproxen as a preferred NSAID over more COX-2 selective agents due to lower cardiovascular risk in patients with cardiovascular disease, although this is irrelevant for carpal tunnel syndrome treatment 1, 2, 3

Cardiovascular Considerations for NSAID Use

  • The American Heart Association suggests that naproxen has a lower cardiovascular risk compared to other NSAIDs, which is a consideration for patients with cardiovascular disease, but not for carpal tunnel syndrome treatment 1, 2, 3