Antibiotic Treatment with Augmentin

Introduction to Augmentin Dosage

The American Academy of Family Physicians recommends Augmentin dosing at 40 mg amoxicillin/kg/day in three doses for Group A streptococcal pharyngitis treatment, and in three doses daily for 10 days for chronic carriers of Group A Streptococcus 1
The Infectious Diseases Society of America (IDSA) guidelines recommend a minimum treatment duration of 5 days, with the patient being afebrile for 48-72 hours before discontinuation, and no more than 1 CAP-associated sign of clinical instability before stopping therapy for community-acquired pneumonia 2

For most infections treated with Augmentin, the dosing schedule is 500 mg twice daily or 250 mg four times daily for adults, as recommended by the American family physician 1
The IDSA guidelines recommend a treatment duration based on clinical stability, with a minimum of 5 days of treatment 2

The short half-lives of both amoxicillin and clavulanic acid necessitate multiple daily doses to maintain effective antimicrobial activity, as evidenced by the need for dosing every 8-12 hours in standard treatment regimens 1
The IDSA guidelines support the need for consistent antibiotic levels throughout the treatment period, which cannot be achieved if therapeutic levels drop significantly between doses 2