Medications Associated with Leg Tremors

High-Risk Medications

• The American Academy of Sleep Medicine recommends against bupropion for restless legs syndrome due to its potential to worsen movement symptoms, with tremor occurring in 7-12% of patients in clinical trials 1, 2
• SSRIs, including fluoxetine, commonly cause sweating, tremors, nervousness, and various gastrointestinal disturbances 3

Medication-Specific Risks

• Gabapentin can cause tremor as a side effect, particularly at higher doses or in patients with renal impairment, despite being used to treat restless legs syndrome 2
• Ondansetron can cause myocardial ischemia through coronary vasospasm, potentially leading to tremor 4

Medications with Lower Risk of Tremor

• Losartan and other angiotensin receptor blockers are associated with drug-induced photosensitivity but not directly with tremor 5
• Finasteride, Rivaroxaban, Omeprazole, Lovastatin, Simethicone, Loperamide, Oxybutynin, and Docusate are not typically associated with tremor 3, 5, 6, 7
• Cetirizine, an antihistamine, can exacerbate restless legs syndrome but is not directly linked to tremor 2