Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/18/2025

Escitalopram and Cognitive Side Effects

Management and Treatment

  • The American Academy of Family Physicians suggests considering dose adjustment or switching to another SSRI, such as sertraline, which may have fewer cognitive side effects, if memory impairment is bothersome 1
  • The American Academy of Family Physicians recommends sertraline as an alternative with potentially fewer cognitive side effects 2
  • Standardized assessment tools should be used to track cognitive symptoms over time, as recommended by Praxis Medical Insights 1