Aripiprazole Dosing Guidelines

Special Populations

• The American Geriatrics Society recommends using lower starting doses for elderly patients 2
• The American Association for the Study of Liver Diseases recommends using lower starting doses for patients with hepatic impairment 2

Other Psychiatric Indications

Autism Spectrum Disorder (Children/Adolescents)

• The American Academy of Child and Adolescent Psychiatry recommends a dose range of 5-15 mg/day for children and adolescents with autism spectrum disorder 3
• Fixed doses of 5, 10, or 15 mg/day have been studied in children ages 6-17, with a response rate of 56% at 5 mg vs 35% on placebo 3
• Common side effects include somnolence, weight gain, drooling, tremor, fatigue, and vomiting 3

PTSD-Related Nightmares

• The American Academy of Sleep Medicine recommends a dose range of 15-30 mg/day for PTSD-related nightmares 1
• Substantial improvement, but not complete resolution, can be expected within 4 weeks 1
• Efficacy has been shown in 4 of 5 veterans studied, with one patient discontinuing due to paradoxical excitement 1

Clozapine Augmentation for Treatment-Resistant Schizophrenia

• The American Psychiatric Association recommends that aripiprazole can be used to augment clozapine when significant positive symptoms persist 4
• Specific dosing for augmentation is not provided in guidelines, but aripiprazole can be used as an adjunct therapy 4

Adolescent Dosing (Ages 13-17) for Schizophrenia

• The American Academy of Sleep Medicine recommends a titration schedule of 2 mg/day on days 1-2, 5 mg/day on days 3-4, and 10 mg/day on day 5 and beyond for adolescents with schizophrenia 1