Pulmicort Nebulizer and Tremor Association
Mechanism and Side Effects
- Beta-agonists such as salbutamol and terbutaline are especially likely to cause tremor, particularly in elderly patients, and high doses should be avoided unless necessary 1
- Bronchodilators like beta-agonists and ipratropium bromide are frequently mixed together in nebulizers with steroids 2, 3
Clinical Considerations and Precautions
- Nebulized budesonide (Pulmicort Respules) is often administered in the same treatment session as bronchodilators 2, 3
- The volume of fluid in nebulizer chambers is usually 2.0-4.5 ml, and bronchodilators are sometimes mixed together to make up this volume 2, 4
- If a patient is experiencing tremor, they should verify whether their nebulizer treatment contains only budesonide or if it has been mixed with a beta-agonist bronchodilator 2
Management and Prevention
- Patients experiencing tremor should contact their prescribing physician to clarify exactly what medications are in their nebulizer solution 2, 7
- If a beta-agonist is included and causing problematic tremor, the patient should discuss dose reduction or alternative delivery methods with their doctor 1
- In elderly patients with ischemic heart disease, high-dose beta-agonist treatment should be used with particular caution, as tremor is more common in this population 1