Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/13/2025

Pulmicort Nebulizer and Tremor Association

Mechanism and Side Effects

  • Beta-agonists such as salbutamol and terbutaline are especially likely to cause tremor, particularly in elderly patients, and high doses should be avoided unless necessary 1
  • Bronchodilators like beta-agonists and ipratropium bromide are frequently mixed together in nebulizers with steroids 2, 3

Clinical Considerations and Precautions

  • Nebulized budesonide (Pulmicort Respules) is often administered in the same treatment session as bronchodilators 2, 3
  • The volume of fluid in nebulizer chambers is usually 2.0-4.5 ml, and bronchodilators are sometimes mixed together to make up this volume 2, 4
  • If a patient is experiencing tremor, they should verify whether their nebulizer treatment contains only budesonide or if it has been mixed with a beta-agonist bronchodilator 2

Management and Prevention

  • Patients experiencing tremor should contact their prescribing physician to clarify exactly what medications are in their nebulizer solution 2, 7
  • If a beta-agonist is included and causing problematic tremor, the patient should discuss dose reduction or alternative delivery methods with their doctor 1
  • In elderly patients with ischemic heart disease, high-dose beta-agonist treatment should be used with particular caution, as tremor is more common in this population 1