Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/25/2025

Glycemic Control in Diabetes Management

Benefits of Glucerna Substitution

  • The American Diabetes Association recommends substituting Glucerna for Jevity 1.5 in patients with diabetes who require better glycemic control, as it may reduce the need for insulin or other glucose-lowering medications 1
  • Substituting Glucerna for Jevity 1.5 is recommended for patients with diabetes and poor glycemic control on standard formula, as it can provide better postprandial glucose control 2, 1

Patient-Specific Considerations

  • The American College of Physicians suggests that patients with diabetes who are at risk for diabetes complications may benefit from improved glycemic control with Glucerna substitution 1, 3
  • Patients with diabetic kidney disease may benefit from the potentially lower protein content in Glucerna compared to Jevity 1.5, according to the American Diabetes Association 5

Practical Implementation

  • The American Association of Clinical Endocrinologists recommends monitoring blood glucose levels closely after changing formulas to assess glycemic response, and adjusting insulin or other diabetes medications as needed based on glycemic response 2, 1
  • A gradual transition between formulas is recommended to minimize gastrointestinal intolerance, as suggested by the American Gastroenterological Association 2