Paracetamol Use After Vaccinations

Recommended Paracetamol Dosage

The recommended dosage of Paracetamol is 10-15 mg/kg body weight every 4-6 hours, without exceeding the maximum daily dose, as suggested by the guideline society, Praxis Medical Insights 1
Prophylactic Paracetamol administration is only recommended for certain risk groups, such as children with a history of seizures, according to the guideline society, Praxis Medical Insights 1

Typical vaccine reactions include fatigue (50%), headache (40%), muscle pain and chills (20%), nausea (20%), and fever (>37.7°C in 10% of cases), as reported by the Centers for Disease Control and Prevention, MMWR Recommendations and Reports 2, 3
Most vaccine reactions occur between day 3-7 after vaccination (78% of cases), according to the Centers for Disease Control and Prevention, MMWR Recommendations and Reports 2, 4
Symptoms are usually self-limiting and only require symptomatic treatment, as stated by the Centers for Disease Control and Prevention, MMWR Recommendations and Reports 4

Topical anesthetics like Lidocain-Prilocain cream (EMLA) can be applied 30-60 minutes before injection to reduce pain, as recommended by the guideline society, Praxis Medical Insights 1
Cold sprays can reduce short-term pain during injection and may be as effective as Lidocain-Prilocain cream, according to the guideline society, Praxis Medical Insights 1

Patients should stay in the office for at least 30 minutes after vaccination to monitor for potential allergic reactions, as advised by the Centers for Disease Control and Prevention, MMWR Recommendations and Reports, and the Journal of Allergy and Clinical Immunology 5, 6
Delayed systemic reactions can occur after the 30-minute waiting period, but are usually not severe, as reported by the Journal of Allergy and Clinical Immunology 6
Biphasic reactions (reoccurrence of symptoms 2-24 hours after the initial reaction) have been observed in up to 23% of patients with systemic reactions after allergen immunotherapy, according to the Journal of Allergy and Clinical Immunology 6