Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/13/2025

Vortioxetine Treatment Duration for Major Depressive Disorder

Treatment Recommendations

  • For a first episode of major depressive disorder, continue treatment for 4 to 9 months after a satisfactory response, as recommended by the American College of Physicians, based on evidence from the Annals of Internal Medicine 1
  • For patients who have had 2 or more episodes of depression, an even longer duration of therapy may be beneficial, according to the American College of Physicians, based on evidence from the Annals of Internal Medicine 1