Safety of Dompéridone During Pregnancy

Introduction to Dompéridone Safety

• The European Association for the Study of the Liver considers dompéridone as probably safe during pregnancy, with limited clinical experience but a low risk profile 1

Recommendations for Use During Pregnancy

• Dompéridone can be used as a second-line antiemetic during pregnancy when first-line treatments fail, according to the European Association for the Study of the Liver 1
• It is considered a therapeutic option for managing hyperemesis gravidarum, with maternal benefits likely to outweigh potential risks during pregnancy 1
• The benefits of dompéridone are thought to outweigh the risks during pregnancy, although exact risks are unknown 2 3

Precautions and Monitoring

• As with any medication used during pregnancy, the benefits and risks of each treatment should be weighed 2 3
• The risk to the mother if left untreated should be considered against the risk of treatment to the newborn 2

Breastfeeding Considerations

• Dompéridone is considered compatible with breastfeeding 4
• It is even used as a galactagogue to stimulate milk production and may increase milk supply 4
• Levels in breast milk are low due to first-pass hepatic and intestinal metabolism 4