Leflunomide Dosage and Efficacy for Rheumatoid Arthritis

Dosing Regimen

• The standard maintenance dose of leflunomide is 20 mg once daily, as recommended by the European League Against Rheumatism, with a similar efficacy to methotrexate and sulfasalazine in clinical trials 1, 2

Alternative Dosing Approaches

• A study comparing a loading dose of leflunomide with a fixed dose of 20 mg daily showed no differences in efficacy but a better safety profile for the fixed dose, as reported by the American College of Rheumatology 3

Special Populations

• Leflunomide has been used as a remission-maintenance therapy at a dose of 20-30 mg/day in patients with renal vasculitis, according to the National Kidney Foundation 4