Storage and Handling of Polysulfated Glycosaminoglycan

General Storage Recommendations

Injectable medications like Adequan should be stored according to manufacturer guidelines to maintain efficacy and prevent degradation, with unopened vials stored in a refrigerator at 2-8°C (36-46°F) without freezing or contamination by food 1
For most medications, once opened, they should be stored at ambient temperatures (15-30°C or 59-86°F) away from direct sunlight until the manufacturer's expiration date (often 28 days) 2
The American College of Physicians recommends checking the temperature of the refrigerator where medications are stored since household refrigerators commonly operate outside the ideal range 2

The Centers for Disease Control and Prevention recommends using cooler packs/insulated bags if transporting Adequan outside in hot or cold/freezing conditions to maintain its stability 2
Before injection, it is essential to check that the medication is not expired and appears visually normal, according to the Mayo Clinic Proceedings 1

Freezing Adequan should be avoided as this can alter its molecular structure and potentially reduce efficacy, as stated by the Mayo Clinic Proceedings 2
The Centers for Disease Control and Prevention advises against storing in frost-free freezers where temperature might cycle above recommended storage temperatures 3
Exposing the medication to direct heat, light, or excessive agitation should be avoided, as recommended by the Mayo Clinic Proceedings 1
The American Diabetes Association recommends not using the medication if there are visible changes in appearance (clumping, frosting, precipitation, or change in clarity or color) 4