Drug Interactions of Metaxalone

Clinical Considerations and Precautions

• The Mayo Clinic recommends that metaxalone should be held on the day of surgical procedures to avoid potentiating anesthetic agents 1
• Patients with hepatic or renal impairment may have altered metaxalone metabolism, potentially increasing interaction risks, according to the Mayo Clinic 1
• Metaxalone is contraindicated in patients with significant hepatic or renal dysfunction, as stated by the Mayo Clinic 1

Perioperative Considerations

• The Mayo Clinic advises that metaxalone should be held on the day of surgical procedures 1
• The combination of metaxalone with anesthetic agents may increase the risk of excessive sedation, as noted by the Mayo Clinic 1