Cefazolin Dosing for Staphylococcal Endocarditis

Recommended Dosage

• In adult patients with staphylococcal endocarditis, guideline recommendations advise cefazolin 100 mg/kg per day given intravenously in divided doses every 8 hours, not to exceed a total daily dose of 12 g. This dosing strategy is intended to achieve adequate drug exposure for severe infection and is supported by multiple 2015 publications in Circulation [​1, 2, 3, 4, 5]. (Strength of evidence not explicitly stated).