Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/24/2025

Cymbalta (Duloxetine) Dosing Considerations

Tolerability and Efficacy

  • The Mayo Clinic recommends starting at 30 mg once daily for 1 week before increasing to 60 mg once daily to reduce nausea, with only transitory impact on effectiveness during the first week 1