Augmentin Dosage and Administration Guidelines

Adult and Pediatric Dosing Recommendations

For animal or human bite infections, the Infectious Diseases Society of America recommends Amoxicillin-clavulanate 875/125 mg twice daily orally 1, 2
For acute bacterial rhinosinusitis in children, the American Academy of Otolaryngology-Head and Neck Surgery recommends Amoxicillin/clavulanate (90 mg/6.4 mg/kg per day) 3
For skin and soft tissue infections, the Infectious Diseases Society of America recommends treatment for 5-7 days after clinical improvement 4
For animal or human bite infections, treatment should continue for 5-7 days 1

For community-acquired pneumonia, the Journal of Microbiology, Immunology and Infection recommends Amoxicillin/clavulanate 1.2 g IV every 8 hours (for moderate severity) 5
For intra-abdominal infections in non-critically ill, immunocompetent patients with adequate source control, the World Journal of Emergency Surgery recommends Amoxicillin/clavulanate 2 g/0.2 g every 8 hours 6

The Infectious Diseases Society of America notes that Amoxicillin-clavulanate is not recommended with probenecid, and may increase prothrombin time with oral anticoagulants 1

The 1.2g dose administered three times daily provides optimal pharmacodynamic coverage for serious bacterial infections requiring hospitalization, as recommended by the Infectious Diseases Society of America 7, 8

Moderate to severe community-acquired pneumonia requiring hospitalization may require TID dosing, as suggested by clinical guidelines 7
Complicated intra-abdominal infections with adequate source control may also benefit from TID dosing, according to the Infectious Diseases Society of America 8
For mild to moderate uncomplicated infections in outpatient settings, BID dosing may be acceptable, as recommended by the Infectious Diseases Society of America 9, 10

Increasing dosing frequency to QID (every 6 hours) may be necessary for optimal bacterial killing in critically ill patients or those with severe sepsis, as suggested by clinical research 8