Prochlorperazine Dosing and Administration

Adult Dosing

The American Academy of Family Physicians recommends a standard dose of prochlorperazine (Stemetil) for adults with nausea and vomiting of 5-10 mg orally three to four times daily, with a maximum of 40 mg per day, or 25 mg as a suppository with a maximum of three doses per 24 hours 1
For migraine-associated nausea, the standard dose is 25 mg orally or by suppository, with a maximum of three doses per 24 hours 1
Administer 20-30 minutes before or with analgesics, NSAIDs, or ergotamine derivatives for migraine-associated nausea 1

Akathisia, pseudo-parkinsonism, and dystonia are potential adverse effects of prochlorperazine 1
Hypotension, tachycardia, and arrhythmias are also potential adverse effects of prochlorperazine 1

Prochlorperazine is contraindicated in patients with CNS depression 1
Prochlorperazine is contraindicated in patients using adrenergic blockers 1
Prochlorperazine is contraindicated in patients with pheochromocytoma 1
Prochlorperazine is contraindicated in patients with seizure disorders 1
Prochlorperazine is contraindicated in patients with GI bleeding or obstruction 1