Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/24/2025

Management of Jaccoud's Arthropathy

Treatment Approach

  • The American College of Rheumatology recommends considering adding methotrexate or azathioprine for inadequate response to first-line therapy, as these immunosuppressants are used for non-renal lupus manifestations 1
  • For refractory cases, mycophenolate mofetil (MMF) has shown superiority over azathioprine in extrarenal SLE, though cost and teratogenicity are considerations 1
  • Early recognition and treatment initiation are crucial, as emphasized by the Annals of the Rheumatic Diseases, to prevent progression of JA deformities 1
  • Regular monitoring for progression and aggressive control of any underlying inflammatory activity are essential for effective management, as recommended by the Annals of the Rheumatic Diseases 1