Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/24/2025

Management of Peristomal Skin Complications

Diagnosis and Assessment

  • The American Gastroenterological Association recommends inspecting for fungal infection characteristics, such as itchy maculopapular rash with satellite borders, typically caused by prolonged moisture and heat under the appliance 1
  • Swabbing the area for both bacterial and fungal culture is necessary to guide targeted therapy, especially in immunocompromised patients 2
  • Assessing for effluent leakage is crucial, as it is the most common cause of peristomal skin damage and creates an environment conducive to fungal overgrowth 1, 3
  • Identifying high-risk features, such as diabetes, obesity, poor nutritional status, and chronic corticosteroid or immunosuppressive therapy, is important, as they significantly increase infection risk 2, 4

Treatment

  • The American College of Gastroenterology recommends cleaning the affected area thoroughly with soap and water, ensuring complete drying, and then sprinkling antifungal powder directly onto the peristomal skin 1, 4
  • Applying skin sealant over the powder is necessary to create a protective barrier that allows the antifungal to work while preventing further moisture accumulation 1
  • Reassessing at 2 weeks is crucial, and if no improvement occurs, the patient requires further evaluation by a surgeon or enterostomal therapist for possible systemic antifungal therapy 1
  • Using stoma adhesive powder or zinc oxide can help prevent local skin irritation 2
  • Considering temporary steroid spray is necessary if allergic contact dermatitis is suspected, which presents with itching and redness in the shape of the appliance 1

Prevention of Effluent Leakage

  • Ensuring proper appliance fit, by cutting the opening one-eighth inch larger than the stoma, can help prevent mucosal irritation while limiting skin exposure 5
  • Optimizing pouching techniques, such as using convex appliances, ostomy belts, paste, or barrier rings, can help bolster stoma height off the peristomal skin 5
  • Heating the appliance with a hair dryer before application and lying flat for several minutes after application can improve the seal 5
  • Ensuring peristomal skin is completely dry before application, using a fine dusting of stomal powder followed by skin sealant if needed, is crucial 5

Special Considerations

  • Immunocompromised patients require a lower threshold for systemic antifungal therapy and daily monitoring for improvement or worsening 2, 4
  • Considering earlier surgical consultation is necessary if infection persists despite appropriate topical treatment 2
  • Maintaining good hygiene with daily cleaning using antimicrobial cleanser is essential 2

Escalation Strategy

  • Adding systemic antifungal agents based on culture results is necessary if topical antifungal treatment fails after 2 weeks 4
  • Considering tube/appliance removal and replacement is necessary if infection persists despite combined topical and systemic therapy 4
  • Evaluating for complications, such as stoma tract disruption, peristomal infection, or severe skin excoriation, is crucial, as they may necessitate surgical intervention 2, 4

REFERENCES

2

Management of Stoma Site Infections [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

3

Peristomal Skin Complications and Management [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

4

Fungal Infection Management at Gastrostomy or Tube Sites [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025