Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/17/2025

Long-Term Pain Management Guidelines

Introduction to Pain Management

  • The British Journal of Anaesthesia recommends that long-term pain management should begin with patient education and supported self-management from the earliest stages, followed by a stepped-care approach that prioritizes non-pharmacological interventions 1, 2

Patient-Centered Care

  • The Annals of the Rheumatic Diseases suggest adopting a patient-centered framework within a biopsychosocial perspective, acknowledging pain as a universal experience that requires comprehensive assessment beyond simple symptom control 3, 4
  • The Annals of the Rheumatic Diseases recommend establishing the patient's functional and valued life goals—specifically what activities they cannot currently perform—rather than focusing solely on pain intensity scores 3, 4

Initial Assessment and Treatment

  • The British Journal of Anaesthesia recommends early identification of patients at high risk for chronic disability, allowing more intensive management, better resource allocation, and reduction in long-term disability 1, 2
  • The Annals of the Rheumatic Diseases suggest that the assessment must systematically evaluate patient needs and priorities, pain characteristics, previous treatments, pain-related factors requiring attention, and underlying pathology 3, 4

Stepped-Care Approach

  • The Annals of the Rheumatic Diseases recommend providing educational materials, delivering psychoeducation, and offering self-management interventions through online or face-to-face programs 3, 4
  • The British Journal of Anaesthesia emphasizes the importance of early implementation of patient education and supported self-management 1, 2

Non-Pharmacological Interventions

  • The Annals of the Rheumatic Diseases suggest that physical activity and exercise interventions demonstrate the most uniformly positive effects on pain across systematic reviews 3, 4
  • The Mayo Clinic Proceedings recommend cognitive behavioral therapy as a first-line non-pharmacological intervention for chronic non-malignant pain treatment 5

Pharmacological Management

  • The Praxis Medical Insights recommend gabapentin as a first-line option for neuropathic pain, titrating to 2400 mg daily in divided doses 6
  • The Praxis Medical Insights suggest acetaminophen as the safest first-line option for musculoskeletal pain, up to 3 grams daily 6, 7

Monitoring and Reassessment

  • The Praxis Medical Insights recommend focusing assessments on achieving functional goals, decreasing pain severity, improving quality of life, and identifying treatment-related adverse events 6
  • The British Journal of Anaesthesia suggests including recommendations for ongoing monitoring in the management plan 1, 2

Special Population Considerations

  • The Praxis Medical Insights recommend avoiding NSAIDs in patients with cirrhosis, kidney disease, or cardiovascular disease, and using acetaminophen as a first-line option instead 7
  • The Praxis Medical Insights suggest adjusting gabapentin dosing based on renal function in patients with kidney disease 7