Rosuvastatin Use in Chronic Kidney Disease

Dosing Recommendations

For patients with severe renal impairment, the American College of Cardiology recommends starting with 5 mg once daily and not exceeding 10 mg once daily 1

The Kidney Disease: Improving Global Outcomes guideline recommends statin or statin/ezetimibe combination for adults ≥50 years with eGFR <60 mL/min/1.73 m², with a strong recommendation (1A) 2, 3
For adults ≥50 years with CKD and eGFR ≥60 mL/min/1.73 m², statin monotherapy is recommended (1B) 2, 3
For adults 18-49 years with CKD, statin therapy is suggested for those with at least one of: coronary disease, diabetes mellitus, prior ischemic stroke, or estimated 10-year cardiovascular risk >10% (2A) 2, 3

The Kidney International guideline suggests choosing statin regimens that maximize absolute reduction in LDL cholesterol to achieve largest treatment benefits 2, 3

Complementing statin therapy with a plant-based "Mediterranean-style" diet may further reduce cardiovascular risk 2, 3