Stopping Depo-Provera for Conception

Understanding Fertility Return

• The American Academy of Pediatrics states that simply stopping Depo-Provera injections and waiting for fertility to return is the recommended approach, as the medication is not reversible once administered 1
• Typical return to fertility occurs 9-18 months after discontinuation, according to the American Academy of Pediatrics 1

Practical Steps to Optimize Conception

• The American Academy of Pediatrics recommends stopping scheduled injections immediately if conception is desired, and planning accordingly as the injection is given every 13 weeks (up to 15 weeks) 1, 2
• Starting prenatal vitamins with folic acid immediately, without waiting for fertility to return, is advised by the American Academy of Pediatrics 1
• Ensuring adequate calcium (1300 mg daily) and vitamin D (600 IU) intake is recommended by the American Academy of Pediatrics, as Depo-Provera causes reversible bone mineral density reductions 1, 2
• Optimizing weight through healthy diet and regular weight-bearing exercise is suggested by the American Academy of Pediatrics 1
• Stopping smoking and limiting alcohol is advised by the American Academy of Pediatrics 1

Special Considerations

• The American College of Obstetricians and Gynecologists does not recommend limiting Depo-Provera use to 2 years despite FDA warnings, recognizing that bone mineral density recovery occurs 2
• If amenorrhea persists beyond 18 months after the last injection, further evaluation is warranted, as this exceeds expected recovery time, according to Praxis Medical Insights 3
• If no conception occurs within 12 months of regular cycles resuming, considering fertility evaluation is recommended by Praxis Medical Insights 3