Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/24/2025

Nerve Deficits and Symptoms from L3-L4 Disc Herniation

Clinical Presentation

  • Patients may experience radicular pain that radiates down the anterior and medial thigh to the knee, according to the American College of Physicians, as reported in the Annals of Internal Medicine 1
  • Depression or absence of the patellar tendon reflex is common, occurring in patients, which is a key diagnostic finding that helps differentiate L3-L4 from other levels of disc herniation, as noted in the Annals of Internal Medicine 1

Diagnostic Considerations

  • MRI without contrast is the preferred imaging modality for confirming L3-L4 disc herniation, as recommended by the American College of Radiology 2
  • MRI without contrast is also preferred by the American College of Radiology for confirming L3-L4 disc herniation, with additional support from 3, 4, and 5

Potential Complications

  • Although rare, cauda equina syndrome can occur with large central disc herniations, presenting with urinary retention, saddle anesthesia, and bilateral lower extremity weakness, as reported in the Annals of Internal Medicine 1 and 6

Differential Diagnosis

  • L4-L5 disc herniation typically affects the L5 nerve root, causing weakness in foot dorsiflexion and great toe extension, according to the American College of Physicians, as reported in the Annals of Internal Medicine 1
  • Lumbar spinal stenosis may present with similar symptoms but typically includes neurogenic claudication, as noted in the Annals of Internal Medicine 6