Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/31/2025

Hyperbolic Tapering of Risperidone

  • The Mayo Clinic recommends allowing 1-2 weeks between dose reductions, though 3-6 months between reductions would be ideal for maximum safety 1

Monitoring During Tapering

  • The American Psychiatric Association suggests monitoring closely for signs of psychotic relapse during and after the tapering process, and being prepared to reinstate antipsychotic treatment immediately if symptoms emerge, particularly in patients with schizoaffective disorder 2

Important Considerations

  • The Mayo Clinic notes that patients with a history of multiple relapses may require more gradual tapering 3

Alternative Approach is not included as there are no citations.

REFERENCES

2

Risk of Psychosis with Antidepressants in Schizoaffective Disorder [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025