Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/16/2025

Insomnia Treatment with Eszopiclone

Clinical Efficacy

  • Studies demonstrate clinically significant reduction in objective sleep latency and increased subjective total sleep time, as recommended by the American Academy of Sleep Medicine 1

Comparison to Other Sleep Medications

  • Eszopiclone is considered a first-line pharmacological option for insomnia, along with other short/intermediate-acting benzodiazepine receptor agonists, according to the American Academy of Sleep Medicine 2
  • Unlike some shorter-acting agents, eszopiclone's relatively longer half-life makes it more effective for sleep maintenance issues, as noted by the American Academy of Sleep Medicine 2

Clinical Practice Algorithm

  • If cognitive behavioral therapy for insomnia (CBT-I) is unsuccessful or unavailable, consider pharmacotherapy with eszopiclone, as suggested by the American Academy of Sleep Medicine, although this particular point is from a different source it is kept for context 2

REFERENCES

1

clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an american academy of sleep medicine clinical practice guideline. [LINK]

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2017

2

clinical guideline for the evaluation and management of chronic insomnia in adults. [LINK]

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2008