Amoxicillin with Azithromycin Regimen for Treating Infections

Specific Regimens by Infection Type

• The American Academy of Pediatrics recommends amoxicillin 90 mg/kg/day in 2 doses with azithromycin 10 mg/kg on day 1, followed by 5 mg/kg/day once daily for days 2-5 for children with community-acquired pneumonia (CAP) 1
• The Centers for Disease Control and Prevention recommends amoxicillin 500 mg orally three times a day for 7 days as a treatment for chlamydial infections in pregnant women 3

Safety Considerations

• The Centers for Disease Control and Prevention advises performing an ECG to assess QTc interval before initiating azithromycin, especially in patients with cardiac risk factors 2
• The Centers for Disease Control and Prevention recommends avoiding azithromycin if QTc is >450 ms for men and >470 ms for women 2

Special Populations

• The Centers for Disease Control and Prevention considers azithromycin safe and effective in pregnancy 3
• The American Academy of Pediatrics recommends amoxicillin 500 mg three times daily for 7 days as a treatment for chlamydial infections in pregnancy 3

Duration of Therapy

• The Infectious Diseases Society of America recommends a 5-day course of azithromycin (500 mg on day 1, then 250 mg daily) for community-acquired pneumonia (CAP) 1
• The Centers for Disease Control and Prevention recommends a 7-day course of amoxicillin (500 mg three times daily) for sexually transmitted infections like chlamydia 3

Antimicrobial Stewardship Considerations

• The Centers for Disease Control and Prevention advises limiting antibiotic exposure whenever possible to minimize development of resistance 2
• The Infectious Diseases Society of America recommends using the shortest effective duration of antimicrobial therapy 2