Susceptibility of Klebsiella pneumoniae to Cefdinir

Introduction to Susceptibility

• The Infectious Diseases Society of America recommends that susceptibility testing for one cephalosporin cannot predict susceptibility to another, particularly when comparing parenteral to oral agents 4, 5, 6

Resistance Mechanisms

• ESBL production is the primary concern with K. pneumoniae and third-generation cephalosporins, with resistance rates to ceftriaxone ranging from 77-88% in many regions globally 2
• ESBL-producing K. pneumoniae shows uniform resistance to cefdinir 1

Clinical Recommendations

• The American College of Clinical Pharmacy recommends that carbapenems remain first-line treatment for ESBL-producing K. pneumoniae 1, 2
• For carbapenem-resistant strains, the Society for Healthcare Epidemiology of America recommends using ceftazidime/avibactam or meropenem/vaborbactam 1, 2