Azithromycin Pharmacokinetics and Pharmacodynamics
Tissue Distribution and Concentration
- The Centers for Disease Control and Prevention recommends azithromycin due to its high tissue distribution, with tissue-to-plasma concentration ratios of:
Clinical Implications
- The CDC suggests that azithromycin is effective in a single 1g dose for infections such as chlamydia 2
- The CDC notes that common side effects of azithromycin include gastrointestinal symptoms (nausea, vomiting, abdominal pain, diarrhea) 1
- The CDC advises caution when administering azithromycin with drugs metabolized by the cytochrome P450 enzyme system 1
- The FDA classifies azithromycin as a category B drug in pregnancy, according to the CDC 1