Cariprazine Use in Patients with Elevated Liver Enzymes

Monitoring and Dosing Recommendations

• Baseline liver function tests should be obtained before starting cariprazine, and regular monitoring of liver function is advisable, particularly in the first few weeks of treatment, as recommended by The Lancet Psychiatry 1
• If significant elevation of liver enzymes occurs or worsens during treatment, consider reducing the dose or discontinuing cariprazine if clinically indicated, as suggested by The Lancet Psychiatry 1
• For patients with moderate hepatic impairment, consider starting at the lower end of the dosing range and monitor liver function tests more frequently during initiation and dose adjustments, according to The Lancet Psychiatry 1