Depo-Provera and Naproxen Interactions

Evidence Supporting Safe Concurrent Use

The U.S. Medical Eligibility Criteria for Contraceptive Use does not list NSAIDs, including naproxen, as having any contraindications or interactions with DMPA, according to the Centers for Disease Control and Prevention 1, 2
Studies examining rivaroxaban with naproxen showed only a 10% increase in drug plasma concentrations when naproxen was co-administered, which is not clinically significant, as reported by the American College of Chest Physicians 3
DMPA maintains its highly effective contraceptive profile (0.2% perfect use failure rate, 6% typical use failure rate) regardless of naproxen co-administration, as stated by the U.S. Medical Eligibility Criteria for Contraceptive Use 4, 5

The American College of Obstetricians and Gynecologists and the Centers for Disease Control and Prevention recommend that naproxen can be safely used with DMPA for pain management, without contraindication 1, 2
The British Association of Dermatologists notes that interactions documented with methotrexate and naproxen do not apply to DMPA, as these are entirely different drug classes with different elimination pathways 6
Heavy or prolonged bleeding patterns in DMPA users can be managed with naproxen without concern for drug interaction, as recommended by the Centers for Disease Control and Prevention 1