Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/24/2025

Hydroxyzine Dosing Considerations for Pediatric Patients

Special Considerations

  • The dose of hydroxyzine should be reduced by half in patients with renal impairment, as recommended by the British Journal of Dermatology 2
  • Hydroxyzine should be avoided in severe renal impairment (creatinine clearance <10 mL/min), according to the British Journal of Dermatology 2
  • Hydroxyzine should be avoided in patients with severe hepatic impairment due to its sedating effects, as suggested by the British Journal of Dermatology and Praxis Medical Insights 2, 1

Administration Considerations

  • Hydroxyzine is available in syrup form, which facilitates administration to children, as noted by Praxis Medical Insights 1

REFERENCES

2

Hydroxyzine Syrup Dosing and Administration in Pediatric Patients [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025