Fluconazole‑Related Dermatologic and Hepatic Adverse Effects

Alternative Antifungal Selection

• Itraconazole (200 mg once daily) can be used safely after a negative drug provocation test because there is no cross‑reactivity with fluconazole in fixed drug eruption cases. [1][2]

Severe Cutaneous Adverse Reactions

• Stevens‑Johnson syndrome (SJS) has been reported in association with fluconazole use, underscoring the need for vigilance for severe cutaneous reactions. [3][4]

General Dermatologic Risks of Fluconazole

• All azole antifungals, including fluconazole, may cause skin rash and pruritus. [3][4]
• Fluconazole use has been linked to alopecia affecting scalp and pubic regions. 3
• Asymptomatic elevations of liver transaminases occur in approximately 1 % to 13 % of patients receiving fluconazole. [3][4]