NSAIDs and Bilirubin Elevation

Hepatotoxicity and Bilirubin Elevation

• The American Academy of Family Physicians notes that hepatic damage from NSAIDs is rare, but these medications should not be used in persons with cirrhotic liver disease because bleeding problems and renal failure become more likely 1
• The American Academy of Family Physicians recommends avoiding NSAIDs in persons with preexisting cirrhosis to prevent acute renal failure 3

Clinical Context: NSAIDs in Liver Disease

• NSAIDs should be avoided in patients with cirrhosis and ascites due to extremely high risk of acute renal failure, hyponatremia, and diuretic resistance 2