Pregabalin Use in Pregnancy

Clinical Considerations

• The American Heart Association, as published in Circulation, recommends that antiepileptic drugs, such as pregabalin, should be avoided in the first trimester when the risk of congenital malformations is greatest, and the use of newer medications during pregnancy may be justified only if benefits clearly outweigh risks, with the lowest recommended dose used initially and adjustments based on clinical response 1
• The American Heart Association, as published in Circulation, suggests considering alternative medications with better established safety profiles during pregnancy if pregabalin must be used for pregnant patients 1
• Failing to discuss alternative treatment options with better established safety profiles is a common pitfall when prescribing pregabalin during pregnancy, according to the American Heart Association, as published in Circulation 1