Amoxicillin-Potassium Clavulanate Efficacy and Guidelines

Clinical Applications

• The European Respiratory Society guidelines recommend using amoxicillin-clavulanate in high dosages (875/125 mg) to achieve concentrations above the MIC of penicillin-resistant strains for lower respiratory tract infections 1, 2
• The European Respiratory Society notes that amoxicillin-clavulanate is active against S. pneumoniae and H. influenzae, making it effective for respiratory infections 1, 2
• The Infectious Diseases Society of America guidelines recognize amoxicillin-clavulanate as effective against beta-lactamase-producing S. aureus, E. coli, and Klebsiella species for skin and soft tissue infections 3
• The World Society of Emergency Surgery guidelines recognize amoxicillin-clavulanate as an option for mild community-acquired intra-abdominal infections 4, 5
• In areas with high prevalence of resistant S. pneumoniae, the European Respiratory Society and the American Academy of Otolaryngology-Head and Neck Surgery guidelines recommend higher doses of amoxicillin-clavulanate 1, 6