Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/25/2025

Vasomotor Symptoms Treatment with Non-Hormonal Options

Non-Hormonal Treatment Approaches

  • The National Comprehensive Cancer Network recommends non-hormonal options like SSRIs/SNRIs and gabapentin for women who cannot take estrogen or prefer non-hormonal options, which have moderate efficacy but different side effect profiles 1
  • Non-pharmacologic approaches like cognitive behavioral therapy may help reduce the perceived burden of hot flashes, as suggested by the National Comprehensive Cancer Network 2, 3
  • Lifestyle modifications, such as weight loss if overweight, smoking cessation, and limiting alcohol if it triggers symptoms, may provide additional benefit in reducing vasomotor symptoms, according to the National Comprehensive Cancer Network 2, 3

REFERENCES

1

survivorship, version 2.2017, nccn clinical practice guidelines in oncology. [LINK]

Journal of the National Comprehensive Cancer Network : JNCCN, 2017

2

survivorship, version 2.2017, nccn clinical practice guidelines in oncology. [LINK]

Journal of the National Comprehensive Cancer Network : JNCCN, 2017

3

survivorship, version 2.2017, nccn clinical practice guidelines in oncology. [LINK]

Journal of the National Comprehensive Cancer Network : JNCCN, 2017