SARI Antidepressants Efficacy and Clinical Use

Clinical Guidelines and Efficacy

• The American Psychiatric Association notes that SARIs have not been adequately studied compared to more established antidepressant classes such as SSRIs and SNRIs 1, 2
• Current clinical guidelines do not include SARIs among first-line recommendations for anxiety disorders due to limited evidence 1, 2, 3
• Japanese guidelines for social anxiety disorder specifically note that SARIs "have not been adequately studied and are thus not included in the guideline with or without recommendations" 2
• The available evidence supports SSRIs and SNRIs as first-line pharmacological treatments for anxiety disorders and depression, with SARIs as alternative options 1, 2, 3