Paroxetine-Associated Hyponatremia

Introduction to Risk

• The American College of Physicians notes that evidence evaluating adverse events such as hyponatremia with second-generation antidepressants, including paroxetine, is scarce but should be kept in mind during treatment 1, 2, 3

Alternative Treatment Options

• When considering alternatives in patients at high risk for hyponatremia, bupropion may have a lower risk profile for this specific adverse effect 3
• For patients with a history of paroxetine-induced hyponatremia, consider alternative antidepressants with lower risk profiles, as suggested by the American Academy of Family Physicians 4