Oncogenic Osteomalacia Treatment
Introduction to Treatment
- The American Journal of Kidney Diseases recommends phosphate supplementation, with a gradual increase in dose until serum phosphate levels are normalized, in patients with oncogenic osteomalacia 2, 3
- The National Kidney Foundation, as reported in Nature Reviews Nephrology, suggests that phosphate supplementation should be administered in 2-4 divided doses, with a preference for potassium-based phosphate salts to reduce the risk of hypercalciuria 1
Medical Treatment
- The American Journal of Kidney Diseases recommends vitamin D supplementation, starting with vitamin D2 or D3, and considering active vitamin D metabolites (calcitriol) if there is no response, in patients with oncogenic osteomalacia 2, 3
- The National Kidney Foundation, as reported in Nature Reviews Nephrology, advises ensuring adequate calcium intake (at least 1g/day) and considering thiazide diuretics to increase renal calcium reabsorption in patients with oncogenic osteomalacia 1
Special Considerations
- The National Kidney Foundation, as reported in Nature Reviews Nephrology, recommends monitoring 25(OH) vitamin D levels and adjusting phosphate supplementation doses as needed during pregnancy, and continuing treatment during lactation 1