Amphetamine Formulations for ADHD Treatment
Introduction to Amphetamine Formulations
- Traditional immediate-release formulations require dosing 2-3 times daily with effects lasting 4-6 hours, according to the American Academy of Child and Adolescent Psychiatry 1
Pharmacokinetics and Efficacy
- All amphetamine preparations work through the same mechanism: inhibiting dopamine and norepinephrine transporters, vesicular monoamine transporter 2, and monoamine oxidase activity, as stated by the Pharmacology and Therapeutics journal 4
- Long-acting formulations generally show better medication adherence and lower risk of rebound effects compared to short-acting versions, as reported by the Pharmacology and Therapeutics journal 4
Dosing and Administration
- The starting dose of standard amphetamine salts is 10 mg once daily in the morning for adults, as recommended by the Praxis Medical Insights 2
- Dose titration typically occurs in 5 mg increments weekly for Adderall XR, with a maximum recommended dose of 50 mg daily for adults, according to the Praxis Medical Insights 2
- Morning administration is crucial for all extended-release formulations to minimize sleep disturbances, as advised by the Praxis Medical Insights 2
Drug Interactions
- Acidifying agents (like ascorbic acid) can decrease amphetamine levels and may require dose adjustments for any amphetamine formulation, as noted by the Praxis Medical Insights 5