Oral Nystatin Treatment Guidelines

Dosage and Administration

• The American Academy of Pediatrics recommends 4-6 mL (400,000-600,000 units) of nystatin suspension four times daily for adults, and alternative treatment with 1-2 nystatin pastilles (200,000 units each) four times daily 1
• The Infectious Diseases Society of America suggests treatment duration of 7-14 days, continuing for at least 48 hours after symptoms resolve 2

Special Considerations

• For vaginal candidiasis, the Centers for Disease Control and Prevention recommends nystatin 100,000-unit vaginal tablets once daily for 14 days 2
• The European Society of Clinical Microbiology and Infectious Diseases recommends oral nystatin 1 mL (100,000 IU) every 8 hours for prevention of invasive candidiasis in neonates 3, 4

Safety and Efficacy

• The Centers for Disease Control and Prevention notes that cutaneous hypersensitivity reactions to nystatin are rare but possible 5