Converting Insulin Aspart to Regular Insulin

Key Principles for Conversion

The American Diabetes Association recommends maintaining the same total daily dose initially when switching from insulin aspart to regular insulin, with adjustments to the timing of administration to 30 minutes before meals 1, 2
The American Association of Clinical Endocrinologists suggests that for basal-bolus regimens, the same basal insulin dose should be maintained when switching between prandial insulins 1, 2

For patients previously on insulin aspart who are switching to regular insulin, the Endocrine Society recommends starting with the same number of units as the previous insulin aspart dose and administering regular insulin 30 minutes before meals instead of immediately before meals 2, 3
The American Diabetes Association advises monitoring blood glucose closely for 3-5 days after switching to determine if dose adjustments are needed, checking blood glucose levels at least 4 times daily during the adjustment period 4

The American Association of Clinical Endocrinologists suggests evaluating glucose patterns over 3-5 days before making additional adjustments, paying special attention to fasting morning glucose levels, 2-hour postprandial values, and signs of hypoglycemia 4