Oral Glutathione Supplementation Guidelines

Clinical Applications and Recommendations

• The American Society for Parenteral and Enteral Nutrition does not recommend oral glutathione supplementation for surgical patients due to insufficient data 1, 2
• The American Society for Parenteral and Enteral Nutrition does not recommend oral glutathione supplementation for cancer patients undergoing chemotherapy, radiotherapy, or hematopoietic stem cell transplantation due to insufficient consistent clinical data 3, 4
• The American Society for Parenteral and Enteral Nutrition does not recommend oral glutathione for radiation-induced complications 3
• Oral glutathione supplementation should not be used as a substitute for established medical therapies in cancer, surgical, or critical care settings 1, 2, 3, 4
• The National Comprehensive Cancer Network advises against the use of oral glutathione in hematopoietic stem cell transplantation, as glutamine supplementation showed more severe oral mucositis and increased relapses 5