Treatment of Reactive Arthritis Triggered by Urinary Tract Infection

Treating the Underlying UTI

For uncomplicated UTI that triggered reactive arthritis, appropriate antimicrobial therapy should be guided by urine culture and susceptibility testing, with empiric treatment options including Amoxicillin plus an aminoglycoside, a second-generation cephalosporin plus an aminoglycoside, or an intravenous third-generation cephalosporin, according to the European Urology guidelines 1
Fluoroquinolones should only be used if local resistance rates are <10% and only when the entire treatment can be given orally, the patient does not require hospitalization, and the patient has anaphylaxis to β-lactam antibiotics, as recommended by the European Urology guidelines 1
Treatment for 7-14 days is generally recommended, with a shorter duration of 7 days considered when the patient is hemodynamically stable and has been afebrile for at least 48 hours, according to the European Urology guidelines 1