Non-Sedating Antihistamines

Classification and Comparison

• The American Academy of Allergy, Asthma, and Immunology identifies fexofenadine as a truly non-sedating antihistamine, even at doses higher than FDA-approved levels, due to its inability to cross the blood-brain barrier 1, 2
• Fexofenadine is classified as a non-sedating antihistamine, similar to loratadine and desloratadine, but unlike cetirizine which may cause sedation at recommended doses 1, 2, 4
• The American Academy of Allergy, Asthma, and Immunology notes that fexofenadine maintains its non-sedating profile even at higher than FDA-approved doses 1, 2

Driving Safety and Performance

• First-generation antihistamines increase the risk of fatal automobile accidents by 1.5 times due to sedation, whereas fexofenadine does not impair driving ability 3, 5